Indian Institute of Technology Guwahati
Department of Biosciences and Bioengineering

Stem Cell and Cancer Biology Group
 

Publications

 

Cancer Biology/Stem Cell Biology

  • Amit Sharma, Trishna Anand, Jina Bhattacharyya, Damodar Das, and Bithiah Grace Jaganathan*. BMP and ERK Signaling Modulate AML-Stroma Interactions and Contextually Alter Cytarabine Sensitivity in AML Cells. Life Sciences. 2026. https://doi.org/10.1016/j.lfs.2026.124507. [Article] 

  • Sreeja Dattachoudhury#, Amit Sharma#, Renu Sharma#, Soumik Pal, Piruthivi Sukumar, and Bithiah Grace Jaganathan*. Downregulation of PIEZO1 Activity Promotes the Survival of Breast Cancer Cells under Shear Stress by Modulating β-Catenin and BCL2. Cancer Research Communications. 2026. https://doi.org/10.1158/2767-9764.CRC-25-0749. [Article] 

  • Amit Sharma, Jina Bhattacharyya, Piruthivi Sukumar*, and Bithiah Grace Jaganathan*. PIEZO1 Modulation Enhances the Stemness of Mesenchymal Stem Cells during Shear Stress and Protects Leukemia Cells from Drug-Induced Cell Death. Scientific Reports. 2025;15:24244. doi:10.1038/s41598-025-09549-z. [Article] 

  • Anupam Bharadwaj, Amalesh Kumar, Sam Padalumavunkal Mathew, Rumela Mitra, Jina Bhattacharyya, Bithiah Grace Jaganathan*, and Bosanta Ranjan Boruah*. Advancing Cellular Insights: Super-Resolution STORM Imaging of Cytoskeletal Structures in Human Stem and Cancer Cells. Biochemistry and Biophysics Reports. 2024;39:101798. doi:10.1016/j.bbrep.2024.101798. [Article] 

  • Rumela Mitra, Ayushi Rehman, Kusum K. Singh*, and Bithiah Grace Jaganathan*. Multifaceted Roles of MAGOH Proteins. Molecular Biology Reports. 2022. doi:10.1007/s11033-022-07904-1. [Article] 

  • Rumela Mitra, M. Aswanth Harish, and Bithiah Grace Jaganathan*. Studying the Role of ERK Inhibition in Glioblastoma Multiforme. In: Lal Mohan Pandey, Rakesh Gupta, Rajesh P. Thummer, and Raj Kumar Kar, editors. Healthcare Research and Related Technologies. Singapore: Springer; 2023.

  • Soumik Pal, Amit Sharma, Sam Padalumavunkal Mathew, and Bithiah Grace Jaganathan*. Targeting Cancer-Specific Metabolic Pathways for Developing Novel Cancer Therapeutics. Frontiers in Immunology. 2022;13. doi:10.3389/fimmu.2022.955476. [Article] 

  • Renu Sharma, Gayatri Gogoi, Snigdha Saikia, Amit Sharma, Deep Jyoti Kalita, Anupam Sarma, Anil Mukund Limaye, Manish Kumar Gaur, Jina Bhattacharyya, and Bithiah Grace Jaganathan*. BMP4 Enhances Anoikis Resistance and Chemoresistance of Breast Cancer Cells through Canonical BMP Signaling. Journal of Cell Communication and Signaling. 2021. doi:10.1007/s12079-021-00649-9. [Article] 

  • Amit Sharma and Bithiah Grace Jaganathan*. Stem Cell Therapy for Retinal Degeneration: The Evidence to Date. Biologics. 2021;15:299-306. [Article] 

  • Sachin Thomas and Bithiah Grace Jaganathan*. Signaling Network Regulating Osteogenesis in Mesenchymal Stem Cells. Journal of Cell Communication and Signaling. 2021. doi:10.1007/s12079-021-00635-1. [Article] 

  • Amit Sharma, Anuja Chakraborty, and Bithiah Grace Jaganathan*. Review of the Potential of Mesenchymal Stem Cells for the Treatment of Infectious Diseases. World Journal of Stem Cells. 2021;13(6):568-593. doi:10.4252/wjsc.v13.i6.568.  [Article]

  • Sanjucta Adak, Damaris Magdalene, Saurabh Deshmukh, Dipankar Das, and Bithiah Grace Jaganathan*. A Review on Mesenchymal Stem Cells for Treatment of Retinal Diseases. Stem Cell Reviews and Reports. 2021. doi:10.1007/s12015-020-10090-x. [Article] 

  • Sreeja Dattachoudhury, Renu Sharma, Atul Kumar, and Bithiah Grace Jaganathan*. Sorafenib Inhibits Proliferation, Migration and Invasion of Breast Cancer Cells. Oncology. 2020;98(7):478-486. doi:10.1159/000505521. [Article] 

  • Darilang Mawrie, Kasturi Bhattacharjee, Amit Sharma, Renu Sharma, Jina Bhattacharyya, Harsha Bhattacharjee, Nilutparna Deori, Atul Kumar, and Bithiah Grace Jaganathan*. Human Orbital Adipose Tissue-Derived Mesenchymal Stem Cells Possess Neuroectodermal Differentiation and Repair Ability. Cell and Tissue Research. 2019. doi:10.1007/s00441-019-03072-0. [Article] 

  • Amit Sharma, Darilang Mawrie, Damaris Magdalene, and Bithiah Grace Jaganathan*. Isolation of Multipotent Mesenchymal Stem Cells from Human Extraocular Muscle Tissue. Bio-protocol. 2019;9(4):e3167. doi:10.21769/BioProtoc.3167. [Article]

  • Renu Sharma, Amit Sharma, Atul Kumar*, and Bithiah Grace Jaganathan*. Phospho-Protein Analysis in Adherent Cells Using Flow Cytometry. Bio-protocol. 2019;9(20):e3395. doi:10.21769/BioProtoc.3395. [Article] 

  • Atul Kumar, Renu Sharma, Sreeja Dattachoudhury, Amit Sharma, Trishna Anand, Jina Bhattacharyya, Kasturi Bhattacharjee, and Bithiah Grace Jaganathan*. OCT4A Transcript Level Correlates with Proliferation Potential of Human Mesenchymal Stem Cells. Gene Reports. 2019. doi:10.1016/j.genrep.2019.100459. [Article] 

  • Atul Kumar, Trishna Anand, Jina Bhattacharyya, Amit Sharma, and Bithiah Grace Jaganathan*. K562 Chronic Myeloid Leukemia Cells Modify Osteogenic Differentiation and Gene Expression of Bone Marrow Stromal Cells. Journal of Cell Communication and Signaling. 2017. doi:10.1007/s12079-017-0412-8. [Article]  

  • Chinnapaka Somaiah#, Atul Kumar#, Renu Sharma#, Amit Sharma, Trishna Anand, Jina Bhattacharyya, Damodar Das, Sewali Deka Talukdar, and Bithiah Grace Jaganathan*. Mesenchymal Stem Cells Show Functional Defect and Decreased Anti-Cancer Effect after Exposure to Chemotherapeutic Drugs. Journal of Biomedical Science. 2018;25:5. doi:10.1186/s12929-018-0407-7. [Article] 

  • Atul Kumar, Jina Bhattacharyya, and Bithiah Grace Jaganathan*. Adhesion to Stromal Cells Mediates Imatinib Resistance in Chronic Myeloid Leukemia through ERK and BMP Signaling Pathways. Scientific Reports. 2017;7:9535. doi:10.1038/s41598-017-10373-3. [Article]  

  • Darilang Mawrie#, Atul Kumar#, Damaris Magdalene, Jina Bhattacharyya, and Bithiah Grace Jaganathan*. Mesenchymal Stem Cells from Human Extra Ocular Muscle Harbor Neuroectodermal Differentiation Potential. PLoS One. 2016;11(6):e0156697. doi:10.1371/journal.pone.0156697. [Article]  

  • Atul Kumar#, Anshuman Bhanja#, Jina Bhattacharyya, and Bithiah Grace Jaganathan*. Multiple Roles of CD90 in Cancer. Tumor Biology. 2016;37:11611. doi:10.1007/s13277-016-5112-0. [Article]

  • Chinnapaka Somaiah, Atul Kumar, Darilang Mawrie, Amit Sarma, Suraj Patil, Jina Bhattacharyya, R. Swaminathan, and Bithiah Grace Jaganathan*. Collagen Promotes Higher Adhesion, Survival and Proliferation of Mesenchymal Stem Cells. PLoS One. 2015;10(12):e0145068. doi:10.1371/journal.pone.0145068. [Article]

  • Himangshu Sonowal, Atul Kumar, Jina Bhattacharyya, Pabitra Kumar Gogoi, and Bithiah Grace Jaganathan*. Inhibition of Actin Polymerization Decreases Osteogenic Differentiation of Mesenchymal Stem Cells through p38 MAPK Pathway. Journal of Biomedical Science. 2013;20(1):71. [Article]  

Interdisciplinary Research

  • Tapashi Sarmah, Soumik Pal, Debasish Barman, Debika Barman, Bithiah Grace Jaganathan*, and Parameswar Krishnan Iyer*. Tailoring Chain-Length in Through-Space Charge-Transfer Donor-σ-Acceptor Multifunctional Emitters for Efficient Long-Term Bioimaging. Advanced Optical Materials. 2025;13. doi:10.1002/adom.202403060. [Article] 

  • Anupam Bharadwaj, Amalesh Kumar, Bithiah Grace Jaganathan, and Bosanta Boruah. piSTORM: Programmable Illumination in Stochastic Optical Reconstruction Microscopy. Optics Letters. 2025. doi:10.1364/OL.575930.

  • P. Vicky Kumar, Soumik Pal, Anil Kumar Birru, Bithiah Grace Jaganathan, and Nelson Muthu. 3D-Printed TPMS-Structured Hybrid PLA/MgTiO3 Scaffolds: Synergizing Bioactivity and Antibacterial Performance for Bone Regeneration. Biomaterials Advances. 2025;177:214370. doi:10.1016/j.bioadv.2025.214370.

  • Mongoli Brahma, Arup Das Kanungo, Minati Das, Sam P. Mathew, Bithiah Grace Jaganathan, and G. Krishnamoorthy. Sensing of Cyanide Ion by Tweaking the Proton Transfer. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 2025;338:126203. doi:10.1016/j.saa.2025.126203. [Article]

  • Anupam Bharadwaj, Amalesh Kumar, Ranjan Kalita, Rumela Mitra, Amit Sharma, Bithiah Grace Jaganathan, Jina Bhattacharyya, Anupam Sarma, Edwin Garcia, Sunil Kumar, Jonathon Lightley, Yuriy Alexandrov, Christopher Dunsby, Mark Neil, P. M. W. French, and Bosanta R. Boruah. Super-Resolved Fluorescence Imaging Utilising Accessible Stochastic Optical Reconstruction Microscopy (easySTORM) Implemented on a Low-Cost, Modular Open-Source Microscope. Measurement Science and Technology. 2024;35. doi:10.1088/1361-6501/ad761b.

  • Amalesh Kumar, Anupam Bharadwaj, Pranjal Choudhury, Sam P. Mathew, Bithiah Grace Jaganathan, and Bosanta R. Boruah. Tuning the Excitation Laser Power in a Stochastic Optical Reconstruction Microscope for Alexa Fluor 647 Dye in Vectashield Mounting Media. Review of Scientific Instruments. 2024;95. doi:10.1063/5.0217409.

  • Anupam Bharadwaj, Amalesh Kumar, Rumela Mitra, Bithiah Grace Jaganathan, and Bosanta R. Boruah. Enhanced Fluorescence Blinking of AF647 Fluorophores in Mowiol via Violet and UV Light-Induced Recovery for Superior Localization Microscopy. Methods and Applications in Fluorescence. 2024;12. doi:10.1088/2050-6120/ad4ae6.

  • Anupam Bharadwaj, Ranjan Kalita, Amalesh Kumar, Anupam Sarma, Bithiah Grace Jaganathan, Sunil Kumar, Frederik Gorlitz, Jonathan Lightley, Christopher Dunsby, Mark Neil, Callum Hollick, Jeremy Graham, P. M. W. French, and Bosanta R. Boruah. A Cost-Effective, Modular, Research-Grade Optical Microscope. Current Science. 2024;126:244-254. doi:10.18520/cs/v126/i2/244-254.

  • Kaushik Kumar Bharadwaj, Bijuli Rabha, Iqrar Ahmad, Chandra Kanta Bhattacharjee, Bithiah Grace Jaganathan, Snigdha Poddar, Harun Patel, Vetriselvan Subramaniyan, Suresh V. Chinni, Gobinath Ramachawolran, Rasha Saleem, Eman Hussain Khalifa Ali, Mohamed M. Abdel-Daim, Debabrat Baishya, and Arabinda Ghosh. Rhamnetin, a Nutraceutical Flavonoid Arrests Cell Cycle Progression of Human Ovarian Cancer (SKOV3) Cells by Inhibiting the Histone Deacetylase 2 Protein. Journal of Biomolecular Structure and Dynamics. 2023. doi:10.1080/07391102.2023.2275187.

Book Chapters

  • Rumela Mitra and Bithiah Grace Jaganathan*. CD90 in Cancer Progression, Metastasis and Chemoresistance. In: Molecular Biomarkers in Cancer: Techniques, Discoveries and Translational Applications. 2023. ISBN:978-1-4438-5758-1.

Previous work

  • Bithiah Grace Jaganathan*, Fernando Anjos-Afonso, Atul Kumar, and Dominique Bonnet*. Active RHOA Favors Retention of Human Hematopoietic Stem/Progenitor Cells in the Niche. Journal of Biomedical Science. 2013;20(1):66. doi:10.1186/1423-0127-20-66. [Article]  

  • Bithiah Grace Jaganathan and Dominique Bonnet. Human Mesenchymal Stem Cells Senesce with Exogenous OCT4. Cytotherapy. 2012;14(9):1054-1063. doi:10.3109/14653249.2012.697145. [Abstract]  

  • Bithiah Grace Jaganathan, Veronica Tisato, Thomas Vulliamy, Inderjeet Dokal, Judith Marsh, Francesco Dazzi, and Dominique Bonnet. Effects of MSC Co-Injection on the Reconstitution of Aplastic Anemia Patient following Hematopoietic Stem Cell Transplantation. Leukemia. 2010;24(10):1791-1795. doi:10.1038/leu.2010.164. [Abstract]

  • Bithiah Grace Jaganathan, Brigitte Ruester, Lars Dressel, Stefan Stein, Manuel Grez, Erhard Seifried, and Reinhard Henschler. Rho Inhibition Induces Migration of Mesenchymal Stromal Cells. Stem Cells. 2007;25(8):1966-1974. [Abstract]  

  • Stephan Gottig, Dietrich Moebest, Brigitte Ruster, Bithiah Grace, Sylvia Winter, Erhard Seifried, Jens Gille, Thomas Wieland, and Reinhard Henschler. Role of Monomeric GTPase Rho in Hematopoietic Progenitor Cell Migration and Transplantation. European Journal of Immunology. 2006;36(1):180-189. [Article]  

  • Brigitte Ruester#, Bithiah Grace#, Oliver Seitz, Erhard Seifried, and Reinhard Henschler. Induction and Detection of Human Mesenchymal Stem Cell Migration in the 48-Well Reusable Transwell Assay. Stem Cells and Development. 2005;14(2):231-235. [Abstract]  

    # Equal contribution

    * Corresponding author 
 
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