Cancer Biology Laboratory

Publications

  • Number of publications >300 (Research articles, Reviews and Book chapters)
  • Cumulative impact factor >1000
  • Average impact factor >7.0
  • Total number of citations >58,000 (Google Scholar)
  • h-index >87 (Google Scholar)
  • i10-index >224 (Google Scholar)

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Selected Publications:

Girisa S, Hegde M, Harsha C, Manteghi N, Longkumer I, Ahmed GN, Baruah MN, Kaul SC, Wadhwa R, Kunnumakkara AB. Mortalin Represents a Promising Therapeutic Target for Oral Cancers: Clinical Relevance and Experimental Evidence for the Activation of Akt/mTOR Signaling. Cancers (Basel). 2025 Aug 30;17(17):2860.
https://doi.org/10.3390/cancers17172860
Kunnumakkara, A. B., Hegde, M., Parama, D., Girisa, S., Kumar, A., Daimary, U. D., Garodia, P., Yenisetti, S. C., Oommen, O. V., & Aggarwal, B. B. (2023). Role of Turmeric and Curcumin in Prevention and Treatment of Chronic Diseases: Lessons Learned from Clinical Trials. ACS pharmacology & translational science, 6(4), 447–518.
https://doi.org/10.1021/acsptsci.2c00012
Hegde, M., Girisa, S., BharathwajChetty, B., Vishwa, R., & Kunnumakkara, A. B. (2023). Curcumin Formulations for Better Bioavailability: What We Learned from Clinical Trials Thus Far?. ACS omega, 8(12), 10713–10746.
https://doi.org/10.1021/acsomega.2c07326
Hegde, M., Kumar, A., Girisa, S., Alqahtani, M. S., Abbas, M., Goel, A., Hui, K. M., Sethi, G., & Kunnumakkara, A. B. (2023). Exosomal noncoding RNA-mediated spatiotemporal regulation of lipid metabolism: Implications in immune evasion and chronic inflammation. Cytokine & growth factor reviews, 73, 114–134.
https://doi.org/10.1016/j.cytogfr.2023.06.001
Hegde, M., Girisa, S., Naliyadhara, N., Kumar, A., Alqahtani, M. S., Abbas, M., Mohan, C. D., Warrier, S., Hui, K. M., Rangappa, K. S., Sethi, G., & Kunnumakkara, A. B. (2023). Natural compounds targeting nuclear receptors for effective cancer therapy. Cancer metastasis reviews, 42(3), 765–822.
https://doi.org/10.1007/s10555-022-10068-w
Hegde, M., Naliyadhara, N., Unnikrishnan, J., Alqahtani, M. S., Abbas, M., Girisa, S., Sethi, G., & Kunnumakkara, A. B. (2023). Nanoparticles in the diagnosis and treatment of cancer metastases: Current and future perspectives. Cancer letters, 556, 216066.
https://doi.org/10.1016/j.canlet.2023.216066
Parama, D., Girisa, S., Khatoon, E., Kumar, A., Alqahtani, M. S., Abbas, M., Sethi, G., & Kunnumakkara, A. B. (2022). An overview of the pharmacological activities of scopoletin against different chronic diseases. Pharmacological research, 179, 106202.
https://doi.org/10.1016/j.phrs.2022.106202
Hegde, M., Girisa, S., Naliyadhara, N., Kumar, A., Alqahtani, M. S., Abbas, M., Mohan, C. D., Warrier, S., Hui, K. M., Rangappa, K. S., Sethi, G., & Kunnumakkara, A. B. (2022). Natural compounds targeting nuclear receptors for effective cancer therapy. Cancer metastasis reviews, 10.1007/s10555-022-10068-w. Advance online publication.
https://doi.org/10.1007/s10555-022-10068-w
Bordoloi, D., Harsha, C., Padmavathi, G., Banik, K., Sailo, B. L., Roy, N. K., Girisa, S., Thakur, K. K., Khwairakpam, A. D., Chinnathambi, A., Alahmadi, T. A., Alharbi, S. A., Shakibaei, M., & Kunnumakkara, A. B. (2022). Loss of TIPE3 reduced the proliferation, survival and migration of lung cancer cells through inactivation of Akt/mTOR, NF-κB, and STAT-3 signaling cascades. Life sciences, 293, 120332.
https://doi.org/10.1016/j.lfs.2022.120332
Naliyadhara, N., Kumar, A., Girisa, S., Daimary, U. D., Hegde, M., & Kunnumakkara, A. B. (2022). Pulsed electric field (PEF): Avant-garde extraction escalation technology in food industry. Trends in Food Science & Technology.
https://doi.org/10.1016/j.tifs.2022.02.019
Brockmueller, A., Mueller, A. L., Kunnumakkara, A. B., Aggarwal, B. B., & Shakibaei, M. (2022). Multifunctionality of Calebin A in inflammation, chronic diseases and cancer. Frontiers in oncology, 12, 962066.
https://doi.org/10.3389/fonc.2022.962066
Gangwar, S. K., Kumar, A., Jose, S., Alqahtani, M. S., Abbas, M., Sethi, G., & Kunnumakkara, A. B. (2022). Nuclear receptors in oral cancer-Emerging players in tumorigenesis. Cancer letters, 536, 215666.
https://doi.org/10.1016/j.canlet.2022.215666
Hegde, M., Daimary, U. D., Jose, S., Sajeev, A., Chinnathambi, A., Alharbi, S. A., Shakibaei, M., & Kunnumakkara, A. B. (2022). Differential Expression of Genes Regulating Store-operated Calcium Entry in Conjunction With Mitochondrial Dynamics as Potential Biomarkers for Cancer: A Single-Cell RNA Analysis. Frontiers in genetics, 13, 866473.
https://doi.org/10.3389/fgene.2022.866473
Hegde, M., Daimary, U. D., Girisa, S., Kumar, A., & Kunnumakkara, A. B. (2022). Tumor cell anabolism and host tissue catabolism-energetic inefficiency during cancer cachexia. Experimental biology and medicine (Maywood, N.J.), 247(9), 713–733.
https://doi.org/10.1177/15353702221087962
. Hegde, M., Daimary, U. D., Kumar, A., Chinnathambi, A., Alharbi, S. A., Shakibaei, M., & Kunnumakkara, A. B. (2022). STAT3/HIF1A and EMT specific transcription factors regulated genes: Novel predictors of breast cancer metastasis. Gene, 818, 146245.
https://doi.org/10.1016/j.gene.2022.146245
Khatoon, E., Banik, K., Harsha, C., Sailo, B. L., Thakur, K. K., Khwairakpam, A. D., Vikkurthi, R., Devi, T. B., Gupta, S. C., & Kunnumakkara, A. B. (2022). Phytochemicals in cancer cell chemosensitization: Current knowledge and future perspectives. Seminars in cancer biology, 80, 306–339.
https://doi.org/10.1016/j.semcancer.2020.06.014
.Arora, L., Mohan, C. D., Yang, M. H., Rangappa, S., Deivasigamani, A., Kumar, A. P., Kunnumakkara, A. B., Garg, M., Chinnathambi, A., Alharbi, S. A., Alahmadi, T. A., Rangappa, K. S., Hui, K. M., Sethi, G., & Ahn, K. S. (2021). Tris(dibenzylideneacetone)dipalladium(0) (Tris DBA) Abrogates Tumor Progression in Hepatocellular Carcinoma and Multiple Myeloma Preclinical Models by Regulating the STAT3 Signaling Pathway. Cancers, 13(21), 5479
https://doi.org/10.3390/cancers13215479
Padmavathi, G., Monisha, J., Bordoloi, D., Banik, K., Roy, N. K., Girisa, S., Singh, A. K., Longkumer, I., Baruah, M. N., & Kunnumakkara, A. B. (2021). Tumor necrosis factor-α induced protein 8 (TNFAIP8/TIPE) family is differentially expressed in oral cancer and regulates tumorigenesis through Akt/mTOR/STAT3 signaling cascade. Life sciences, 287, 120118.
https://doi.org/10.1016/j.lfs.2021.120118
Bordoloi, D., Padmavathi, G., Banik, K., Devi, K. A., Harsha, C., Girisa, S., Buhrmann, C., Shakibaei, M., & Kunnumakkara, A. B. (2021). Human tumor necrosis factor alpha-induced protein eight-like 1 exhibited potent anti-tumor effect through modulation of proliferation, survival, migration and invasion of lung cancer cells. Molecular and cellular biochemistry, 476(9), 3303–3318.
https://doi.org/10.1007/s11010-021-04060-1
Aswathy, M., Banik, K., Parama, D., Sasikumar, P., Harsha, C., Joseph, A. G., Sherin, D. R., Thanathu, M. K., Kunnumakkara, A. B., & Vasu, R. K. (2021). Exploring the Cytotoxic Effects of the Extracts and Bioactive Triterpenoids from Dillenia indica against Oral Squamous Cell Carcinoma: A Scientific Interpretation and Validation of Indigenous Knowledge. ACS pharmacology & translational science, 4(2), 834–847.
https://doi.org/10.1021/acsptsci.1c00011
Bordoloi, D., Banik, K., Vikkurthi, R., Thakur, K. K., Padmavathi, G., Sailo, B. L., Girisa, S., Chinnathambi, A., Alahmadi, T. A., Alharbi, S. A., Buhrmann, C., Shakibaei, M., & Kunnumakkara, A. B. (2020). Inflection of Akt/mTOR/STAT-3 cascade in TNF-α induced protein 8 mediated human lung carcinogenesis. Life sciences, 262, 118475.
https://doi.org/10.1016/j.lfs.2020.118475
Singh, A. K., Roy, N. K., Bordoloi, D., Padmavathi, G., Banik, K., Khwairakpam, A. D., Kunnumakkara, A. B., & Sukumar, P. (2020). Orai-1 and Orai-2 regulate oral cancer cell migration and colonisation by suppressing Akt/mTOR/NF-κB signalling. Life sciences, 261, 118372.
https://doi.org/10.1016/j.lfs.2020.118372
Banik, K., Ranaware, A. M., Harsha, C., Nitesh, T., Girisa, S., Deshpande, V., Fan, L., Nalawade, S. P., Sethi, G., & Kunnumakkara, A. B. (2020). Piceatannol: A natural stilbene for the prevention and treatment of cancer. Pharmacological research, 153, 104635.
https://doi.org/10.1016/j.phrs.2020.104635
Bordoloi, D., Banik, K., Padmavathi, G., Vikkurthi, R., Harsha, C., Roy, N. K., Singh, A. K., Monisha, J., Wang, H., Kumar, A. P., & Kunnumakkara, A. B. (2019). TIPE2 Induced the Proliferation, Survival, and Migration of Lung Cancer Cells Through Modulation of Akt/mTOR/NF-κB Signaling Cascade. Biomolecules, 9(12), 836.
https://doi.org/10.3390/biom9120836
Khwairakpam, A. D., Banik, K., Girisa, S., Shabnam, B., Shakibaei, M., Fan, L., Arfuso, F., Monisha, J., Wang, H., Mao, X., Sethi, G., & Kunnumakkara, A. B. (2020). The vital role of ATP citrate lyase in chronic diseases. Journal of molecular medicine (Berlin, Germany), 98(1), 71–95.
https://doi.org/10.1007/s00109-019-01863-0
Bordoloi, D., Monisha, J., Roy, N. K., Padmavathi, G., Banik, K., Harsha, C., Wang, H., Kumar, A. P., Arfuso, F., & Kunnumakkara, A. B. (2019). An Investigation on the Therapeutic Potential of Butein, A Tretrahydroxychalcone Against Human Oral Squamous Cell Carcinoma. Asian Pacific journal of cancer prevention : APJCP, 20(11), 3437–3446.
https://doi.org/10.31557/APJCP.2019.20.11.3437
Haque, M. A., Sailo, B. L., Padmavathi, G., Kunnumakkara, A. B., & Jana, C. K. (2018). Nature-inspired development of unnatural meroterpenoids as the non-toxic anti-colon cancer agents. European journal of medicinal chemistry, 160, 256–265.
https://doi.org/10.1016/j.ejmech.2018.08.088
Monisha, J., Roy, N. K., Padmavathi, G., Banik, K., Bordoloi, D., Khwairakpam, A. D., Arfuso, F., Chinnathambi, A., Alahmadi, T. A., Alharbi, S. A., Sethi, G., Kumar, A. P., & Kunnumakkara, A. B. (2018). NGAL is Downregulated in Oral Squamous Cell Carcinoma and Leads to Increased Survival, Proliferation, Migration and Chemoresistance. Cancers, 10(7), 228.
https://doi.org/10.3390/cancers10070228

Books Published

Molecular Targets and Therapeutic Uses of Spices.
Modern Uses for Ancient Medicine

By Bharat B. Aggarwal, Ajaikumar B. Kunnumakkara (2009)

The Chemistry and Bioactive Components of Turmeric.

by Ajaikumar B Kunnumakkara, Augustine Amalraj, Bharat B Aggarwal, Sabu Thomas, Sreeraj Gopi (Oct,2020)

Cancer Cell Chemoresistance and Chemosensitization.

by Ajaikumar B Kunnumakkara, Devivasha Bordoloi, Javadi Monisha (April,2018)

Anticancer Properties of Fruits and Vegetables
A Scientific Review

by Ajaikumar B Kunnumakkara (Dec,2014)

Fusion Genes And Cancer.

by Ajaikumar B Kunnumakkara, Ganesan Padmavathi, Nand Kishor Roy (April,2017)

Inflammation and Natural Products.

by Ajaikumar B. Kunnumakkara, Augustine Amalraj, Sabu Thomas, Sreeraj Gopi (Jan,2021)